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- $Unique_ID{BRK01130}
- $Pretitle{}
- $Title{What Causes an "Autoimmune" Disease to Happen?}
- $Subject{autoimmune disease Blood lymphocytes T cells thymus B cell blood
- antibodies phagocytes neutrophils macrophages juvenile rheumatoid arthritis ra
- systemic lupus erythematous le multiple sclerosis diabetes phagocyte
- neutrophil macrophage}
- $Volume{U-7}
- $Log{
- Rheumatoid Arthritis*0001703.scf
- Neutrophil and Monocyte (White) Blood Cells*0002104.scf
- Lymphocyte(White) Blood Cells*0002105.scf
- Location and Function of the Endocrine Glands*0002901.scf
- The Thymus*0002908.scf
- Immune Cell Production Sites I*0004501.scf
- Immune Cell Production Sites II*0004502.scf
- Symptoms of Multiple Sclerosis*0008201.scf}
-
- Copyright (c) 1991-92,1993 Tribune Media Services, Inc.
-
-
- What Causes an "Autoimmune" Disease to Happen?
-
-
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-
- QUESTION: Although I think I understand what the body does to protect itself
- against harmful bacteria that cause infections, I don't understand the cause
- of something called an "autoimmune" disease. Yet I read every day of more
- illness blamed on this process. Can you explain what it is and what causes it
- to happen?
-
- ------------------------------------------------------------------------------
-
- ANSWER: I can probably handle "what it is" a bit better than what causes it
- to happen. And I would be at a complete loss in trying to identify methods to
- treat the problem directly. The immune process is a complicated one, with
- several types of cells playing important roles in the process. There are two
- important lymphocytes, T cells (for thymus) and B cells (for blood) that are
- at the core of the action. The T cell is like a quarterback that interprets
- the enemy's composition and signals other cells to get into action. B cells
- eliminate any enemies that exist outside of cells, such as viral organisms
- which may have multiplied inside a normal cell, broken out and are now on the
- prowl for new healthy cell victims. B cells recognize these enemies with the
- help of antibodies, molecules that form part of the surface of the B cell. T
- cells, along with "helper" T cells and "suppressor" T cells, direct the
- action, getting cells known as phagocytes (neutrophils and macrophages) to
- attack the enemy and literally eat them up. All of this works quite well
- normally, but sometimes the system goes out of whack, and these cells begin to
- attack cells within our body that are part of our normal systems. For some
- reason they have been identified as "foreign" by the immune system, and all of
- the forces normally directed to ridding the body of invaders are directed
- against natural portions of our own constitution. Such parts may be joints,
- as in juvenile rheumatoid arthritis, or organs--the kidneys or lungs--which
- become victims in systemic lupus erythematous. In multiple sclerosis it is
- the brain and spinal cord, and in juvenile diabetes the pancreas is affected.
- Thus the protective system works against its own body or "autoimmune", as if
- we were allergic to ourselves. The only treatments now available attempt to
- reduce the process of inflammation, or attempt to reduce symptoms. Though we
- still don't know enough, this is a field of medicine that has made enormous
- strides recently, a science that was mostly unknown when I attended medical
- school.
-
- ----------------
-
- The material contained here is "FOR INFORMATION ONLY" and should not replace
- the counsel and advice of your personal physician. Promptly consulting your
- doctor is the best path to a quick and successful resolution of any medical
- problem.
-
-